Categories and examples of Immunodeficiency

• Primary Immunodeficiency (intrinsic cause = usually genetic)
• Secondary Immunodeficiency (extrinsic cause = non-iatrogenic)
• Immunosuppression (extrinsic cause = iatrogenic)

Clinical approach to Managing Immunodeficiency

Primary Immunodeficiency syndromes

Chronic Granulomatous Disease (CGD)

Chediak-Higashi syndrome

Leukocyte adhesion deficiency

B-cell disorders

Common Variable Immunodeficiency (CVID)

Bruton's (x-linked) congenital agammagolinaemia

Selective immunoglobulin A deficiency

T-cell disorders

DiGeorge syndrome

Combined B and T cell disorders

Severe combined immunodeficiency