These coniditons are types of SCARs

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) may be associated with a preceding history of medication use, most commonly anticonvulsants, antibiotics, and non-steroidal anti-inflammatory drugs. Other associated factors include infections.

Erythema multiform - less severe form

SJS - Severe skin detachment with mucosal complications - an autoimmune reaction to foreign bodies

TEN - More severe form

Classification is dependant on % of skin involvement:

• SJS has <10% total body surface area (TBSA) involvement
• SJS/TEN overlap has 10% to 30% TBSA involvement
• TEN has >30% TBSA involvement

Risk factors:

• Anticonvulsant meds -
  • carbamazepine
  • phenytoin
  • Lamotrigine
  • valproic acid
  • Phenobarbitol
• Other meds: Recent antibiotic use, allopurinol, NSAIDs
• Smallpox vaccine
• Recent infection - Mycoplasma pneumoniae, herpes, EBV, cytomegalovirus

PC

*Presence of risk factors

• Rash