Sepsis is a clinical syndrome resulting from a dysregulated immune response to infection

It is characterised by derangements in multiple pathobiological processes, which may lead to widespread tissue injury. It encompasses a clinical spectrum of severity, including severe sepsis, septic shock, and multi-organ failure.

Sepsis is a leading cause of morbidity and mortality in children worldwide.

definition for septic shock in children: 'severe infection leading to cardiovascular dysfunction (including hypotension, need for treatment with a vasoactive medication, or impaired perfusion)’

Risk factors:

• Immunodeficiency
• Co-morbidities
• Younger age
• Recent surgery or invasive procedures
• Breached skin integrity

PC

• Fever or low body temp
• Tachypnoeia
• Tachycardia
• Bradycardia (<1 year with sepsis may present with bradycardia)
• Altered mental state/consciousness
• Crying - high pitched or weak cry
• Decreased peripheral perfusion