Restrictive cardiomyopathy involves non-dilated non-hypertrophied ventricles with impaired ventricular filling.

Causes

• Familial non-infiltrative cardiomyopathy (inherited genetic disorders)
• Infiltrative:
  • Amyloidosis
  • Sarcoidosis
  • Gaucher disease
  • Hurler syndrome
  • Fatty infiltration
• Storage:
  • Haemochromatosis
  • Fabry disease
  • Glycogen storage disorders
• Others:
  • Diabetic cardiomyopathy
  • Scleroderma
  • Hypereosinophilic syndrome (Löffler's)
  • Radiation
  • Chemotherapy (anthracyclines like Doxorubicin and Daunorubicin)

PC

Presentation is often that of heart failure or sometimes similar to that of constrictive pericarditis. Up to 75% of patients will have associated atrial fibrillation.

Investigations

• Echocardiogram (which shows thickened ventricular walls and valves)
• cardiac MRI (which is useful for distinguishing between restrictive cardiomyopathy and constrictive pericarditis).