AKA diffuse proliferative glomerulonephritis

Post-streptococcal glomerulonephritis typically occurs 7-14 days following GABHS (streptococcus pyogens), patients develop a nephritic syndrome

It is caused by immune complex (IgG, IgM and C3) deposition in the glomeruli. Young children are most commonly affected.

Occurs 1-2 weeks after a streptococcal throat infection

2-6 weeks after a streptococcal skin infection

PC

• general
  • headache
  • malaise
• occasionally visible haematuria (however main Sx is proteinuria)
• oedema - due to proteinuria
• oliguria

Investigations

Bedside

• hypertension
• Urine dipstick
  • proteinuria
  • Haematuria

bloods:

• low C3
• raised ASO titre - a blood test to measure antibodies against streptolysin O, a substance produced by group A streptococcus bacteria.