NAS refers to withdrawls symptoms that happen in neonates of mothers that used substances in pregnancy

Substances that cause NAS

• Opiates
• Methadone
• Benzodiazepines
• Cocaine
• Amphetamines
• Nicotine or cannabis
• Alcohol
• SSRI antidepressants

Clinical features

Withdrawal from most opiates, diazepam, SSRIs and alcohol occurs between 3 – 72 hours after birth. Withdrawal from methadone and other benzodiazepines occurs between 24 hours and 21 days.

CNS:

• Irritability
• Increased tone
• High pitched cry
• Not settling
• Tremors