Triptans

Triptans are used to abort migraines when they start to develop. They are 5HT receptors agonists (serotonin receptor agonists). They have various mechanisms of action and it is not clear which mechanisms are responsible for their effects on migraines. They act on:

• Smooth muscle in arteries to cause vasoconstriction
• Peripheral pain receptors to inhibit activation of pain receptors
• Reduce neuronal activity in the central nervous system