Mucosa associated lymphoid tissue (MALT) lymphoma is a rare low grade non-Hodgkin's lymphoma that usually presents in the stomach, but can present elsewhere. It develops from B lymphocytes in the marginal zone.

It is strongly associated with H. Pylori infection and chronic inflammation and autoimmune conditions are risk factors.

PC

• Abdominal pain
• Nausea and vomiting
• Symptoms of anaemia
• Weight loss

Management

• The initial treatment for local and disseminated disease is H. Pylori eradication therapy. This can treat the lymphoma in many cases.
• If this fails to eradicate the disease, however, other treatment options are chemotherapy and radiotherapy. These may be considered if the disease is progressive or the patient has high risk features, such as being H. Pylori negative at presentation.
• In disseminated disease, chemotherapy and rituximab is recommended if there is a threat to vital organ function. Otherwise, a watch and wait approach can be adopted.