Can be primary lesions or secondary mets

Most cancers cause lytic lesions

• Increase in osteoclastic activity = lytic lesion
• Increase in osteoblastic activity = sclerotic lesion
• Mixed sclerotic and lytic bone lesions:breast cancer

Main cancers that metastasise to bones:

• Po – Prostate
• R – Renal
• Ta – Thyroid
• B – Breast
• Le – Lung

Most common tumour causing bone metastases (in descending order)

• prostate
• breast
• lung

Most common site (in descending order)

• spine
• pelvis