• Autoimmune diseases can be multisystem or single system diseases, most are multi-system. Organ specific vs non organ specific

Single system - coeliac disease

Multisystem -

• Rheumatoid arthritis (RA)
• Systemic lupus erythematosus (SLE)
• Primary Sjogren’s syndrome
• Systemic sclerosis
• Ankylosing spondylitis (AS)
• Primary vasculitis e.g. Granulomatous polyangiitis (GPA)

PC in patients with autoimmune rheumatic diseases:

Secondary Raynaud’s phenomenon (NB primary RP is normal in 10% of people)

Joint pains – warm, worse in morning

Rashes – sometimes photosensitive (face, arms, chest)

Fatigue – Not all patients with fatigue have autoimmune disease, ask about autoimmune symptoms

Investigations: